PXI-6221
May 27, 2026

PXI-6221

I. Product Introduction The PXI-6221 is a 3U single-slot PXI multifunction DAQ module of the NI M series (Multifunction). It features 16-bit, 250 kS/s, 16-channel AI, 2-channel AO, 24-channel DIO, and 2-channel counter. It strikes a balance between accuracy, speed, and channel count, positioning itself as a mid-to-high performance, versatile measurement and control device, suitable for laboratory and industrial environments.

Description

II. Model Interpretation

PXI: 3U single slot, PXI bus (compatible with PXI/PXIe chassis)

6221: M series multi-function DAQ, 16-bit, 250 kS/s, 16AI/2AO

M series: Multi-function, combining the features of E series high-density and S series high-precision

Part number: 779629-01 (standard), 779113-01 (SCXI control board)

III. Technical Parameters (25℃)

1. Analog Input (AI)

Channels: 16 single-ended / 8 differential (software selectable)

Resolution: 16 bits (no bit loss)

Sampling Rate: Total 250 kS/s (shared by multiple channels)

Range: ±0.2 V, ±1 V, ±5 V, ±10 V (programmable)

Input Impedance: >10 GΩ || 100 pF

Coupling: DC; Overvoltage Protection ±11 V (signal + common mode)

CMRR: 92 dB (DC–60 Hz)

FIFO: 8 k samples, supports DMA

2. Analog Output (AO)

Channels: 2 channels

Resolution: 16 bits

Range: ±10 V

Update Rate: 833 kS/s (per channel)

Drive: ±5 mA

3. Digital I/O (DIO)

Channels: 24 bidirectional TTL/CMOS

Level: High ≥ 2.4 V, Low ≤ 0.4 V

Rate: Up to 1 MHz (hardware timing)

4. Counter / Timer

Quantity: 2 channels 32 bits (80 MHz base)

Function: Event counting, frequency / period, pulse output, edge triggering

5. Physical and Environmental

Size: 3U single slot (approx. 22×124×126 mm)

Operating Temperature: 0~55℃

Power Consumption: Approximately 6.5 W

Calibration: Suggested once per year for traceability calibration

IV. Interface and Communication Configuration

Front panel interface: 68-pin SCSI-II female connector (with SH68-68-EP cable, CB-68LP wiring box)

Bus: Standard PXI (PCI, trigger, 10 MHz reference clock)

Driver: NI-DAQmx, supports LabVIEW, Python, C#, TestStand

Synchronization: PXI trigger bus / RTSI, multi-module synchronization

PFI lines: 8 programmable function inputs for triggering and timing routing

V. Core Functions

16-bit high-precision acquisition: High resolution, precise capture of small signals, excellent dynamic range.

Flexible channel configuration: 16 single-ended / 8 differential selectable, suitable for different sensors and interference environments.

Medium-high-speed continuous acquisition: 250 kS/s total sampling rate + 8 kFIFO, supports long-term streaming.

Multifunction integration: AI + AO + DIO + counter, one module completes measurement / control / timing.

Wide range and conditioning compatibility: 4 range settings; expandable SCXI/SCC high voltage / isolation conditioning.

VI. Application Scenarios

Industrial automation testing: Synchronous measurement and control of voltage / current / temperature at multiple nodes in production lines.

Research laboratory measurement: Sensor signals, biomedical signals, low-frequency vibration acquisition.

Electronic manufacturing ATE: PCB functional testing, component parameter measurement, closed-loop control.

Small-scale structural modal analysis: Multi-channel vibration / strain testing (non-ultra-high synchronization requirements).

Cost-sensitive high-precision system: Balanced accuracy, speed and budget for general measurement and control.

VII. Usage and Maintenance Instructions

Installation and Power On

Disconnect power, insert card, chassis grounded; After powering on, NI-DAQmx performs self-check and preheats for 15 minutes.

Operating temperature: 0–55℃. Keep the air duct unobstructed and avoid blocking the fan.

Wiring and operation

For analog input, use differential wiring (for strong interference environments), with shielded twisted pair.

Input voltage should not exceed ±10 V; avoid frequent plugging and unplugging of the 68-pin interface and recommend using a wiring box.

Multi-module synchronization: Share the PXI 10 MHz reference clock and trigger bus.

Daily maintenance and calibration

It is recommended to conduct a traceable calibration once a year; built-in self-calibration compensates for temperature drift.

Keep the interface clean, prevent dust accumulation during long-term inactivity; keep away from strong vibrations, condensation and strong electromagnetic interference.


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